Research on L-carnitine began in the early 20th century. In 1905, Russians Gulewitsch and Krimberg discovered L-carnitine from meat extracts. Since then, scientists from various countries have conducted in-depth research. Early studies found that L-carnitine is a vitamin-like nutrient and has been Named vitamin Bt. In fact, the chemical structure of alkali is similar to choline and similar to amino acids; in addition, because some animals can synthesize it by themselves to meet the needs of carnitine, it is considered that carnitine is not a vitamin, but it is still customarily called vitamin BT.

The Food and Nutrition Board of the National Academy of Sciences extensively reviewed research on L-carnitine and concluded in 1989 that "L-carnitine is not an essential nutrient" and does not require a "recommended intake." At the International Nutrition Academic Conference held in Chicago in 1985, L-carnitine was designated as a "multifunctional nutritional product".

In 2003, L-carnitine was recognized by the International Obesity Health Organization as the safest nutritional supplement for weight loss without side effects.

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